Metagenomic next-generation sequencing helped diagnose scrub typhus without eschar: A case report

Metagenomic next-generation sequencing helped diagnose scrub typhus without eschar: A case report

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Background: Scrub typhus is caused by Orientia tsutsugamushi.Clinical manifestations include fever, rash, eschar at the bite site, and other non-specific flu-like symptoms.The eschar is a dark, scab-like area at the bite site, and is the ealisboa.com typical lesions that prompts a diagnosis of O.tsutsugamushi.Without eschar lesions, it is difficult to identify scrub typhus.

However, metagenomic next-generation sequencing (mNGS) can be used to identify infections, and this novel method may help improve clinical diagnosis.Case presentation: Here, we report a iphone 14 price arizona case of scrub typhus in a 51-year-old woman who presented to the emergency department with a week-long fever from an unknown cause.We used mNGS to search for an infectious etiology, and the mNGS suggested O.tsutsugamushi, which was unexpectedly detected.Discussion and conclusion: This study suggests that mNGS may be a useful diagnostic tool to identify clinical, causative pathogens in fever, particular ones with atypical features.

Keywords: Next-generation sequencing, Orientia tsutsugamushi, Fever, Eschars.